Comprehensive Review Research Articles

From Gut to Glucose: A Comprehensive Review on Functional Foods and Dietary Interventions for Diabetes Management.

In the realm of diabetes research, considerable attention has been directed toward elucidating the intricate interplay between the gastrointestinal tract and glucose regulation. The gastrointestinal tract, once exclusively considered for its role in digestion and nutrient assimilation, is presently acknowledged as a multifaceted ecosystem with regulatory supremacy over metabolic homeostasis and glucose metabolism. Recent studies indicate that alterations in the composition and functionality of the gut microbiota could potentially influence the regulation of glucose levels and glucose homeostasis in the body. Dysbiosis, characterized by perturbations in the equilibrium of gut microbial constituents, has been irrevocably linked to an augmented risk of diabetes mellitus (DM). Moreover, research has revealed the potential influence of the gut microbiota on important factors, like inflammation and insulin sensitivity, which are key contributors to the onset and progression of diabetes. The key protagonists implicated in the regulation of glucose encompass the gut bacteria, gut barrier integrity, and the gut-brain axis. A viable approach to enhance glycemic control while concurrently mitigating the burden of comorbidities associated with diabetes resides in the strategic manipulation of the gut environment through adapted dietary practices. This review aimed to provide a deep understanding of the complex relationship between gut health, glucose metabolism, and diabetes treatment. This study has presented an exhaustive overview of dietary therapies and functional foods that have undergone extensive research to explore their potential advantages in the management of diabetes. It looks into the role of gut health in glucose regulation, discusses the impact of different dietary elements on the course of diabetes, and evaluates how well functional foods can help with glycemic control. Furthermore, it investigates the mechanistic aspects of these therapies, including their influence on insulin sensitivity, β-cell activity, and inflammation. It deliberates on the limitations and potential prospects associated with integrating functional foods into personalized approaches to diabetes care.

Nutritional Fuelling for Microgravity Environment of Space Missions

Abstract: Since the beginning of space missions, the food systems have undergone a sea change with prolonged manned missions and permanent space habitats. We have a better understanding of physiological changes which happen in humans in space and help in adaptation to the space environment. Yet, much remains underexplored and warrants further research. Space missions today involve a considerable number of individuals operating in a microgravity environment for both short and long periods. The provision of food for such missions and managing the physio-pathological changes that affect nutritional requirements continue to be challenging. Food systems (food and beverages) used during every program to date have been shelf‐stable and were composed primarily of rehydratable or thermostabilized food items. Such foods usually have a lower hedonic value than fresh or frozen foods. Consequently, a reliable food system must provide a wide range of palatable and attractive foods as well as the tools to prepare them (through rehydration, heating, and cooling) to enhance the taste sensation of the crew. Adequate nutrition with easily accessible food is essential to this effort. To deliver nutritional recommendations to crew members for long-duration space missions, it is important to understand how nutritional status and general physiology are linked and affected by microgravity exposure. In view of this, it has been pointed out that nutritional countermeasures could rectify the physiological and behavioural anomalies during microgravity exposure. In this comprehensive narrative review, we have provided an overview of a few recent advances such as silkworm protein, good mood-vegan diet, 3-D food printing, and space garden’s produce for onboard support to food systems. It has also been found that exercise could be an addition to nutritional interventions. Areas of space exploration that require more in-depth research using ground-based bed rest models, as well as inflight microgravity conditions, are highlighted.

A Comprehensive Review of Modern Methods for Load Prediction in the Smart Grid

: Load forecasting plays a crucial role in mitigating risks for utilities by predicting future usage of commodity markets transmission or supplied by the utility. To achieve this, various techniques such as price elastic demand, climate and consumer response, load analysis, and sustainable energy generation predictive modelling are used. As both supply and demand fluctuate, and weather and power prices can rise significantly during peak periods, accurate load forecasting becomes critical for utilities. By providing brief demand forecasts, load forecasting can assist in estimating load flows and making decisions that prevent overloading. Therefore, load forecasting is crucial in helping electric utilities make informed decisions related to power, load switching, voltage regulation, switching, and infrastructure development. Forecasting is a methodology used by electricity companies to forecast the amount of electricity or power production needed to maintain constant supply as well as load demand balance. It is required for the electrical industry to function properly. The smart grid is a new system that enables electricity providers and customers to communicate in real-time. The precise energy consumption sequence of the consumers is required to enhance the demand schedule. This is where predicting the future comes into play. Forecasting future power system load (electricity consumption) is a critical task in providing intelligence to the power grid. Accurate forecasting allows utility companies to allocate resources and assume system control in order to balance the same demand and availability for electricity. In this article, a study on load forecasting algorithms based on deep learning, machine learning, hybrid methods, bio-inspired techniques, and other techniques is carried out. Many other algorithms based on load forecasting are discussed in this study. Different methods of load forecasting were compared using three performance indices: RMSE (Root Mean Square Error), MAE (Mean Absolute Error), MAPE (Mean Absolute Percentage Error), and Accuracy. Machine learning-based techniques showed a reduction of 9.17% in MAPE, 0.0429% in RMSE, and 5.23% in MSE, and achieved 90% accuracy. Deep learning-based techniques resulted in a 9.61% decrease in MAPE and achieved 91% accuracy. Bioinspired techniques provided a reduction of 9.66% in MAPE, 0.026% in RMSE, and 5.24% in MSE, and achieved 95% accuracy. These findings concluded that optimization techniques are more encouraging in predicting load demand and, as a result, can represent a reliable decision-making tool.

Unveiling Diabetes: Categories, Genetics, Diagnostics, Treatments, and Future Horizons.

Diabetes mellitus is a global epidemic affecting millions of individuals worldwide. This comprehensive review aims to provide a thorough understanding of the categorization, disease identity, genetic architecture, diagnosis, and treatment of diabetes. The categorization of diabetes is discussed, with a focus on type 1 and type 2 diabetes, as well as the lesser-known types, type 3 and type 4 diabetes. The geographical variation, age, gender, and ethnic differences in the prevalence of type 1 and type 2 diabetes are explored. The impact of disease identity on disease management and the role of autoimmunity in diabetes are examined. The genetic architecture of diabetes, including the interplay between genotype and phenotype, is discussed to enhance our understanding of the underlying mechanisms. The importance of insulin injection sites and the insulin signalling pathway in diabetes management are highlighted. The diagnostic techniques for diabetes are reviewed, along with advancements for improved differentiation between types. Treatment and management approaches, including medications used in diabetes management are presented. Finally, future perspectives are discussed, emphasizing the need for further research and interventions to address the global burden of diabetes. This review serves as a valuable resource for healthcare professionals, researchers, and policymakers, providing insights to develop targeted strategies for the prevention, diagnosis, and management of this complex disease.

Curriculum Approaches in English Language Teaching in Indonesia

This study used library research research methods to investigate curriculum approaches in English language teaching in Indonesia. The purpose of this study is to identify curriculum approaches commonly used in English language teaching in Indonesia and to understand how these approaches shape teaching methods and strategies applied in language classrooms. In this study, the author conducted a comprehensive literature review of relevant literature, including textbooks, research journals, articles, and education policies related to English language teaching in Indonesia. The data collected were analyzed qualitatively to identify curriculum approaches commonly used in the context of English language teaching in Indonesia. The results of this study show that some curriculum approaches commonly used in English teaching in Indonesia include content-based approaches, communicative approaches, task-based approaches, and grammar-based approaches. The selection of this curriculum approach is based on the goals and objectives of the program, as well as the needs and interests of learners. In conclusion, in Indonesia, English teaching is influenced by various curriculum approaches, which shape the methods and strategies applied in language classes. The choice of curriculum approach in English language teaching depends on the goals and objectives of the program, as well as the needs and interests of learners. Different approaches can be used in combination to create a comprehensive and effective language learning experience so that language learners can easily master the language in a formal setting.

An All-Inclusive Taxonomy and Critical Review of Blockchain-Assisted Authentication and Session Key Generation Protocols for IoT

Authentication and Session Key Generation Protocols (SKGPs) play an essential role in securing the communication channels of connected Internet of Things (IoT) devices. Recently, through blockchain integration, scholars have tried to enhance the security and applicability of SKGPs. In brief, blockchain is a distributed ledger technology that can provide interesting features such as immutability, transparency, and accountability without any need for the active participation of trusted parties. This survey presents a comprehensive critical review of blockchain-assisted authentication and SKGPs, suggested for different IoT domains, including Internet of Vehicles, Internet of Drones, and Industrial IoT. Our survey categorizes existing schemes based on several criteria, including IoT application domains, security aspects, and blockchain components. By presenting an unbiased critical review and taxonomy of protocols, we aim to clarify the key challenges. Our review will specifically indicate what properties authors gained or lost through the integration of blockchain. To our best knowledge, this survey is the only one that offers all prerequisites for interested readers in blockchain-integrated SKGPs, such as security features and attacks, attack models, verification tools, blockchain types, blockchain platforms, and consensus mechanisms. Further, our survey elaborates existing research gaps in blockchain-assisted SKGPs. In doing so, we aim to guide future research in this field and provide researchers with the essential information they require.

Recent Advances of Aminopeptidases-Responsive Small-Molecular Probes for Bioimaging.

Aminopeptidases, enzymes with critical roles in human body, are emerging as vital biomarkers for metabolic processes and diseases. Aberrant aminopeptidase levels are often associated with diseases, particularly cancer. Small-molecule probes, such as fluorescent, fluorescent/photoacoustics, bioluminescent, and chemiluminescent probes, are essential tools in the study of aminopeptidases-related diseases. The fluorescent probes provide real-time insights into protein activities, offering high sensitivity in specific locations, and precise spatiotemporal results. Additionally, photoacoustic probes offer signals that are able to penetrate deeper tissues. Bioluminescent and chemiluminescent probes can enhance in vivo imaging abilities by reducing the background. This comprehensive review is focused on small-molecule probes that respond to four key aminopeptidases: aminopeptidase N, leucine aminopeptidase, Pyroglutamate aminopeptidase 1, and Prolyl Aminopeptidase, and their utilization in imaging tumors and afflicted regions. In this review, the design strategy of small-molecule probes, the variety of designs from previous studies, and the opportunities of future bioimaging applications are discussed, serving as a roadmap for future research, sparking innovations in aminopeptidase-responsive probe development, and enhancing our understanding of these enzymes in disease diagnostics and treatment.

A comprehensive review on different types of fuel cell and its applications

This review article provides an overview of various types of fuel cells that are currently being researched and developed. Fuel cells are electrochemical devices that convert chemical energy directly into electrical energy, making them a promising technology for clean and efficient energy production. The review covers the principles of operation and key characteristics of proton exchange membrane fuel cells (PEMFCs), solid oxide fuel cells (SOFCs), alkaline fuel cells (AFCs), direct methanol fuel cells (DMFCs), and microbial fuel cells (MFCs). The article also discusses the advantages and limitations of each type of fuel cell, as well as the current research and development efforts aimed at improving their performance and reducing their costs. Overall, this review provides a comprehensive understanding of the various types of fuel cells and their potential applications in the field of energy production.

A Comprehensive Review on Potential Molecular Drug Targets for the Management of Alzheimer's Disease.

Alzheimer's disease (AD) is an onset and incurable neurodegenerative disorder that has been linked to various genetic, environmental, and lifestyle factors. Recent research has revealed several potential targets for drug development, such as the prevention of Aβ production and removal, prevention of tau hyperphosphorylation, and keeping neurons alive. Drugs that target numerous ADrelated variables have been developed, and early results are encouraging. This review provides a concise map of the different receptor signaling pathways associated with Alzheimer's Disease, as well as insight into drug design based on these pathways. It discusses the molecular mechanisms of AD pathogenesis, such as oxidative stress, aging, Aβ turnover, thiol groups, and mitochondrial activities, and their role in the disease. It also reviews the potential drug targets, in vivo active agents, and docking studies done in AD and provides prospects for future drug development. This review intends to provide more clarity on the molecular processes that occur in Alzheimer's patient's brains, which can be of use in diagnosing and preventing the condition.

A Comprehensive Review on Chemistry and Biology of Tafamidis in Transthyretin Amyloidosis.

Transthyretin amyloid cardiomyopathy and Transthyretin amyloid peripheral neuropathy are progressive disease conditions caused by Transthyretin amyloidosis (ATTR) fibril infiltration in the tissue. Transthyretin (TTR) protein misfolding and amyloid fibril deposits are pathological biomarkers of ATTR-related disorders. There are various treatment strategies targeting different stages in pathophysiology. One such strategy is TTR tetramer stabilization. Recently, a new TTR tetramer stabilizer, tafamidis, has been introduced that reduces the protein misfolding and amyloidosis and, consequently, disease progression in ATTR cardiomyopathy and peripheral neuropathy. This review will provide a comprehensive overview of the literature on tafamidis discovery, development, synthetic methods, pharmacokinetics, analytical methods and clinical trials. Overall, 7 synthetic methods, 5 analytical methods and 23 clinical trials have been summarized from the literature.

Comprehensive Review on Recent Strategies for Management of Prostate Cancer: Therapeutic Targets and SAR.

Prostate cancer is a disease that is affecting a large population worldwide. Androgen deprivation therapy (ADT) has become a foundation for the treatment of advanced prostate cancer, as used in most clinical settings from neo-adjuvant to metastatic stage. In spite of the success of ADT in managing the disease in the majority of men, hormonal manipulation fails eventually. New molecules are developed for patients with various hormone-refractory diseases. Advancements in molecular oncology have increased understanding of numerous cellular mechanisms which control cell death in the prostate and these insights can lead to the development of more efficacious and tolerable therapies for carcinoma of the prostate. This review is focused on numerous therapies that might be a boon for prostate therapy like signaling inhibitors, vaccines, and inhibitors of androgen receptors. Along with these, various bioactive molecules and their derivatives are highlighted, which act as potential anti-prostate cancer agents. This article also emphasized the recent advances in the field of medicinal chemistry of prostate cancer agents.

Flavonoid-metal ion Complexes as Potent Anticancer metallodrugs: A comprehensive Review.

Flavonoids and their analogous are mainly found in pink lady apples, green and black tea (catechins), celery and red peppers, onions, broccoli and spinach, berries, cherries, soybean, citrus fruits, and fungi. The different derivatives of flavonoids belonging to polyphenolic compounds such as 3,4',5,7-Tetrahydroxyflavylium (pelargonidin), 2-(3,4-Dihydroxyphenyl)chromenylium-3,5,7-triol (cyanidin), 3,3',4',5,5',7-Hexahydroxyflavylium (delphinidin), 3,3',4',5,7-Pentahydroxy-5'-methoxyflavylium (petunidin), and 3,4',5,7-Tetrahydroxy-3',5'-dimethoxyflavylium (malvidin) can act as good chelating agents for metal-chelate complex formation. These flavonoid-metal complexes have been reported to have various biomedical and pharmacological activities. Flavonoid-metal ion complexes display a broad spectrum of biological properties such as antioxidant, anti-inflammatory, anti-allergic, antiviral, anticarcinogenic, and cytotoxic activity. The literature survey showed that flavonoid metal complexes have potential therapeutic properties against various cancerous cells. The objective is to gain insight into the current perspective and development of novel anticancer metallodrug drugs. The flavonoid-metal ion complexes can be prepared by reacting flavonoid ligand with appropriate metal salt in aqueous or alcoholic reaction medium under stirring or refluxing conditions. In this review article, the various reported methods for the synthesis of flavonoid-metal complexes have been included. The utility of synthetic methods for flavonoid-metal complexes will support the discovery of novel therapeutic drugs. In this review study, short libraries of flavonoid-metal ion complexes were studied as potential anticancer agents against various human cancer cell lines. The review report reveals that metal ions such as Fe, Co, Ni, Cu, Zn, Rh, Ru, Ga, Ba, Sn etc., when binding to flavonoid ligands, enhance the anticancer activity compared to free ligands. This review study covered some important literature surveys for the last two decades. It has been concluded that flavonoid metal complexes have been associated with a wide range of biological properties that could be noteworthy in the medicinal field. Therefore, to develop a new anticancer drug, it is essential to determine the primordial interaction drug with DNA under physiological or anatomical conditions. The study of numerous flavonoid metal complexes mentioned in this paper could be the future treatment against various cancerous diseases.

Alpha-band Brain Dynamics and Temporal Processing: An Introduction to the Special Focus.

For decades, the intriguing connection between the human alpha rhythm (an 8- to 13-Hz oscillation maximal over posterior cortex) and temporal processes in perception has furnished a rich landscape of proposals. The past decade, however, has seen a surge in interest in the topic, bringing new theoretical, analytic, and methodological developments alongside fresh controversies. This Special Focus on alpha-band dynamics and temporal processing provides an up-to-date snapshot of the playing field, with contributions from leading researchers in the field spanning original perspectives, new evidence, comprehensive reviews and meta-analyses, as well as discussion of ongoing controversies and paths forward. We hope that the perspectives captured here will help catalyze future research and shape the pathways toward a theoretically grounded and mechanistic account of the link between alpha dynamics and temporal properties of perception.

Therapeutic Potential of Piperine: A Comprehensive Review

Abstract: Piperine, an alkaloid from black pepper, has demonstrated diverse pharmacological properties and potential therapeutic applications. Piperine content varies with the pepper plant and ranges from 2 to 7.4% in black pepper. Piperine possesses remarkable biological properties, including antioxidant, anti-inflammatory, antibacterial, anticancer, neuroprotective, and hepatoprotective qualities. Its ability to affect numerous signaling pathways and biological targets implicated in disease development is responsible for these functions. Studies have shown piperine to have high antioxidant activity, which aids in reducing oxidative stress and preventing cellular damage. It has been established that its anti-inflammatory effects suppress the generation of pro-inflammatory mediators, thereby relieving inflammation-related diseases. This review emphasizes and examines piperine's medical and health-promoting benefits and proposed mechanisms of action in health promotion and illness prevention.

Molecular Pathway, Epidemiological Data and Treatment Strategies of Fungal Infection (Mycoses): A Comprehensive Review.

The recent increase in fungal infections is a health crisis. This surge is directly tied to the increase in immunocompromised people caused by changes in medical practice, such as the use of harsh chemotherapy and immunosuppressive medicines. Immunosuppressive disorders such as HIV have exacerbated the situation dramatically. Subcutaneous or superficial fungal infections can harm the skin, keratinous tissues, and mucous membranes. This category includes some of the most common skin disorders that impact millions of people worldwide. Despite the fact that they are seldom fatal, they can have a catastrophic impact on a person's quality of life and, in rare situations, spread to other people or become obtrusive. The majority of fungal infections under the skin and on the surface are simply and quickly cured. An opportunistic organism that preys on a weak host or a natural intruder can both result in systemic fungal infections. Furthermore, it might be exceedingly lethal and dangerous to one's life. Dimorphic fungi may pose a hazard to healthy populations that are not exposed to endemic fungi. Increased surveillance, the availability of quick, noninvasive diagnostic tests, monitoring the emergence of antifungal medication resistance, and research on the pathophysiology, prevention, and management of fungal infections are just a few potential solutions to these new health problems. The goal of this review is to summarize the data available for fungal infections and the different therapies which are involved in their treatment. Additionally, it also summarizes the molecular and scientific data of the plants which contain anti-fungal activity. Data are acquired using Google, PubMed, Scholar, and other online sources.

Autoimmune responses and therapeutic interventions for systemic lupus erythematosus: a comprehensive review.

Systemic Lupus Erythematosus (SLE) or Lupus is a multifactorial autoimmune disease of multiorgan malfunctioning of extremely heterogeneous and unclear etiology that affects multiple organs and physiological systems. Some racial groups and women of childbearing age are more susceptible to SLE pathogenesis. Impressive progress has been made towards a better understanding of different immune components contributing to SLE pathogenesis. Recent investigations have uncovered the detailed mechanisms of inflammatory responses and organ damage. Various environmental factors, pathogens, and toxicants, including ultraviolet light, drugs, viral pathogens, gut microbiome metabolites, and sex hormones trigger the onset of SLE pathogenesis in genetically susceptible individuals and result in the disruption of immune homeostasis of cytokines, macrophages, T cells, and B cells. Diagnosis and clinical investigations of SLE remain challenging due to its clinical heterogeneity and hitherto only a few approved antimalarials, glucocorticoids, immunosuppressants, and some nonsteroidal anti-inflammatory drugs (NSAIDs) are available for treatment. However, the adverse effects of renal and neuropsychiatric lupus and late diagnosis make therapy challenging. Additionally, SLE is also linked to an increased risk of cardiovascular diseases due to inflammatory responses and the risk of infection from immunosuppressive treatment. Due to the diversity of symptoms and treatment-resistant diseases, SLE management remains a challenging issue. Nevertheless, the use of next-generation therapeutics with stem cell and gene therapy may bring better outcomes to SLE treatment in the future. This review highlights the autoimmune responses as well as potential therapeutic interventions for SLE particularly focusing on the recent therapeutic advancements and challenges.

The Impact of Polycystic Ovary Syndrome (PCOS) on the Risk of Developing Ovarian Cancer and Thyroid Disorders: A Comprehensive Review.

Polycystic ovary syndrome (PCOS) is a common hormonal disorder that affects women. It is characterized by hyperandrogenism, polycystic ovarian morphology, and other related disorders. It is associated with various health conditions, such as infertility and increased risk of heart problems. Ovarian cancer is also a significant concern, as it is the fifth leading cause of death in women. While there is evidence suggesting a potential association between PCOS and ovarian cancer, the exact nature of this relationship remains unclear. Thyroid disorders, particularly hypothyroidism and Hashimoto's thyroiditis, have also been linked to PCOS. The presence of hypothyroidism can contribute to the development of polycystic ovarian morphology, affecting ovulation and hormone balance. Many works have shown a higher ubiquity of autoimmune thyroid disease in PCOS patients, indicating a potential association between the two conditions. The occurrence of PCOS, hirsutism, and acne underscores the frequency of endocrine disorders in women. This review paper examines the present relevant work on the association between PCOS and ovarian cancer as well as PCOS and thyroid disorders. A systematic literature search was conducted on PubMed, such as PubMed, Scopus, and Google Scholar database, to identify peer-reviewed publications pertaining to PCOS, ovarian cancer, and thyroid disorders. While some studies have delineated a significant link between PCOS and ovarian cancer or thyroid disorders, others have yielded inconclusive results. Further research is necessary to establish a definitive causal relationship between these conditions. Understanding the relationship between PCOS, ovarian cancer, and thyroid disorders is crucial for early detection, accurate diagnosis, and effective management of these conditions. Identifying potential risk factors and developing appropriate screening strategies can improve women's health outcomes and reduce the burden associated with these disorders.

Proposed fog computing-enabled conceptual model for semantic interoperability in internet of things

Semantic interoperability has emerged as a key barrier amidst the major developments and challenges brought about by the rapid expansion of internet of things (IoT) applications. Establishing interoperability is essential for IoT systems to function optimally, especially across diverse organizations. Despite extensive research in achieving semantic interoperability, dynamic interoperability, a vital facet, remains inadequately addressed. This paper addresses this gap by presenting a fog-based conceptual model designed to facilitate dynamic semantic interoperability in IoT. The model incorporates a single-tier fog layer, providing the necessary processing capabilities to achieve this goal. The study conducts a comprehensive literature review on semantic interoperability, emphasizing latency, bandwidth, total cost, and energy consumption. Results demonstrate the proposed double skin façade (DSF) model’s remarkable 88% improvement in service delay over IoT-SIM and Open IoT, attributed to its efficient load-offloading mechanism and optimized fog layer, offering a 50% reduction in service delay, power consumption, and 86% reduction in network usage compared to existing approaches through data redundancy elimination via pre-processing at the fog layer.

Advances in ground heat exchangers for space heating and cooling: Review and perspectives

As a renewable energy source, geothermal energy has been widely used to provide space heating and cooling for buildings. The thermal performance of ground heat exchanger (GHE) is significant for the operating efficiency of the ground source heat pump (GSHP) systems. This paper presents a comprehensive review of developments and advances of three kinds of GHE, including vertical borehole GHE (VBGHE), Pile GHE (PGHE), and deep borehole GHE (DBGHE) which are currently popular in larger GSHP systems. Firstly, analytical models proposed to analyze heat transfer process of VBGHE with different geological conditions are summarized, such as homogenous or heterogeneous ground, with or without groundwater advection. Numerical and short-time step models and measures to improve GHE thermal performance are also reviewed. Secondly, a summary of research advances in PGHE is provided, which includes the heat transfer models of PGHE, the effects of geometric structure, operation modes, pile spacing, use of phase change material (PCM), thermal properties of PCM, thermo-mechanical behavior and/or thermal performance of PGHE. The effects of groundwater flow direction and velocity on PGHE are also summarized in brief. Lastly, models of three kinds of DBGHEs, i.e., deep coaxial GHE (DCGHE), deep U-bend GHE (DUGHE) and super-long gravity heat pipe (SLGHP), are reviewed. The physical bases of the different analytical models are elaborated and also their advantages and disadvantages are described. Advances in numerical modelling and improving numerical model calculation speed of DCBHE, DCBHE array, and DUBHE are summarized. The review provides a meaningful reference for the further study of GHEs.

The Search for Antidotes Against Ricin.

The castor plant (Ricinus communis) is primarily known for its seeds, which contain a unique fatty acid called ricinoleic acid with several industrial and commercial applications. Castor seeds also contain ricin, a toxin considered a chemical and biological warfare agent. Despite years of investigation, there is still no effective antidote or vaccine available. However, some progress has been made, and the development of an effective treatment may be on the horizon. To provide an updated overview of this issue, we have conducted a comprehensive review of the literature on the current state of research in the fight against ricin. This mini-review is based on the reported research and aims to address the challenges faced by researchers, as well as highlight the most successful cases achieved thus far. Our goal is to encourage the scientific community to continue their efforts in this critical search.